The School of Communication and Computer Sciences at
Ecole Polytechnique Federale de Lausanne (EPFL), Lausanne, Switzerland
together with the
Novartis Institute for BioMedical Research (NIBR), Basel, Switzerland
is inviting applications for a postdoctoral fellow in the field of
Computational Drug-Target Identification.
The position is funded by the Swiss Initiative in Systems Biology (SystemsX.ch) and is hosted by the systems biology group of Dr. Koeppl at the Laboratory of Nonlinear Systems, EPFL. Goal of this interdisciplinary project is to assess the feasibility and performance of agent-based modeling approaches for applied pathway modeling and for in silico drug intervention analysis. The case study considered is the TOR (Target of Rapamycin) signaling pathway in yeast. Planned steps are – (1) documentation of known TOR-pathway-related events in a formal and executable agent-based representation, (2) equipping those events with kinetics through dedicated measurements and development of new calibration algorithms and finally (3) validating the kinetic model in perturbation scenarios and identifying optimal intervention points through the development of a generalized sensitivity analysis.
We are seeking outstanding candidates with a firm mathematical and computational background as well as experience in dynamical modeling of biochemical reaction networks. The candidate may hold a Ph.D. degree in computer science, applied mathematics, physics, electrical engineering, bioinformatics or biochemistry. The position will initially be filled for one year and is extendable upon positive evaluation. The yearly gross salary amounts to CHF 90k. Candidates should send their publication list and CV including contact details of at least three references per email (in a single pdf) to:
Dr. Heinz Koeppl
Laboratory of Nonlinear Systems
School of Communication and Computer Sciences
Ecole Polytechnique Federale de Lausanne (EPFL)
Tel.: +41 21 693 2734
Application deadline: 28.02.2010 (although applications will be considered until the position is filled)